Table of Contents

1. Introduction
2. Understanding Rubella
3. Rubella IgG vs. IgM
4. Clinical Significance
5. QL Biotech Company Solutions
6. References

Introduction

Rubella, commonly known as German measles, is a contagious viral infection best known by its distinctive red rash. To assess immunity and diagnose acute infection, serological testing for IgG and IgM antibodies is essential.

Understanding Rubella

Rubella is caused by the Rubella virus and is usually mild in children but can be serious in pregnant women, potentially leading to congenital rubella syndrome.

Rubella IgG vs. IgM

IgG Antibodies

IgG antibodies are indicative of past infection or immunization. Presence of these antibodies suggests immunity. In quantitative terms, a typical interpretation might consider IgG levels above 10 IU/mL as immune.

IgM Antibodies

IgM antibodies indicate a recent infection. Elevated levels are typically seen in the first week of illness. A significant result can be cited as levels above 1.1 index in a standard ELISA test, signifying acute infection.

Clinical Significance

The distinction between IgG and IgM antibodies helps in determining the phase of infection—whether the individual has been recently infected, has a past infection, or is immune due to vaccination.

QL Biotech Company Solutions

QL Biotech is at the forefront of developing advanced diagnostic kits for Rubella. Their Rubella IgG and IgM ELISA kits provide rapid and precise measurements, with results for IgG having a sensitivity of 98% and specificity of 97%, and IgM kits showing sensitivity of 95% and specificity of 96%.

References

• Centers for Disease Control and Prevention. Rubella: For Healthcare Providers. CDC.
• World Health Organization. Rubella Fact Sheet. WHO.
• QL Biotech Company. Product Information Sheets for Serological Testing Kits.